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Neurodegeneration
A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice.
Krajnak K, Dahl R.
Bioorg Med Chem Lett. 2018 May 15;28(9):1591-1594.

A new target for Parkinson's disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats.
Dahl R.
Bioorg Med Chem. 2017 Jan 1;25(1):53-57.

Small molecule SUMOylation activators are novel neuroprotective agents.
Krajnak K, Dahl R.
Bioorg Med Chem Lett. 2018 28: 405-409.

ER Stress
Cytoprotective small molecule modulators of endoplasmic reticulum stress.
Munshi S, Dahl R.
Bioorg Med Chem. 2016 Jun 1;24(11):2382-8

Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy.
Sano R, Hou YC, Hedvat M, Correa RG, Shu CW, Krajewska M, Diaz PW, Tamble CM, Quarato G, Gottlieb RA, Yamaguchi M, Nizet V, Dahl R, Thomas DD, Tait SW, Green DR, Fisher PB, Matsuzawa S, Reed JC.
Genes Dev. 2012 May 15;26(10):1041-54.

Diabetes
Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders.
Kang S, Dahl R, Hsieh W, Shin A, Zsebo KM, Buettner C, Hajjar RJ, Lebeche D.
J Biol Chem. 2016 Mar 4;291(10):5185-98.

Screening
Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells.
Gruber SJ, Cornea RL, Li J, Peterson KC, Schaaf TM, Gillispie GD, Dahl R, Zsebo KM, Robia SL, Thomas DD.
J Biomol Screen. 2014 Feb;19(2):215-22.

High-throughput FRET assay yields allosteric SERCA activators.
Cornea RL, Gruber SJ, Lockamy EL, Muretta JM, Jin D, Chen J, Dahl R, Bartfai T, Zsebo KM, Gillispie GD, Thomas DD.
J Biomol Screen. 2013 Jan;18(1):97-107.